Hos Geldiniz

677C>T and 1298A>C Polymorphisms of Methylenetetrahydropholate Reductase Gene and Biochemical Parameters in Turkish Population with Spina Bifida Occulta.

Yazan: admin Tarih: Åžub 5th, 2010 | Kategori:: Methylenetetrahydropholate Reductase

Turk Neurosurg. 2010 Jan;20(1):9-15.

Eser B, Cosar M, Eser O, Erdogan MO, Aslan A, Yildiz H, Boyaci G, Buyukbas S, Solak M.

Selcuk , Meram Faculty of Medicine, Department of Medical Genetics, Konya, .

AIM: This study aimed to investigate the 677C > T and 1298A > C MTHFR polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. MATERIAL and METHODS: A case-control study was performed to detect 677C > T and 1298A > C MTHFR polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR polymorphisms. RESULTS: 677 CC/CT/TT MTHFR frequency differences between the SBO patients and controls were not significant (x(2)=3.325, P=0.068; x(2)=1.479, P=0.224; x(2)=0.275, P=0.600; respectively). 1298A > C MTHFR frequency differences between the SBO patients and controls were significant (x(2)=8.477, P=0.004). The frequencies of the Aand C alleles of the 1298A > C did not differ in a statistically significant manner between the groups (x(2)=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P > 0.05). CONCLUSION: The 677C > T and 1298A > C polymorphisms of the MTHFR cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.


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Angiotensin-Converting Enzyme Gene Polymorphism in Overweight and Obese Turkish Patients with Insulin Resistance.

Yazan: admin Tarih: Åžub 5th, 2010 | Kategori:: polymorphisms

DNA Cell Biol. 2010 Jan 13.

Akin F, Turgut S, Bastemir M, Turgut G, Kursunluoglu R, Karasu U, Guclu A.

1 Department of Endocrinology and Metabolism, Faculty of Medicine, Pamukkale , Denizli, .

The aim of this study was to analyze the distribution of the insertion/deletion (I/D) of the angiotensin-converting enzyme (ACE) in obese Turkish patients with insulin resistance (IR). Sixty-two obese Turkish patients with IR were enrolled in this study. One hundred healthy people without IR were recruited as the control group. ACE amplification was performed by chain reaction. The frequency of the DD was significantly higher in obese patients with IR than in control subjects. Of sixty-two patients, 1 (1.6%) had an II , 22 (35.5%) had an ID , and 39 (62.9%) had a DD . The frequency of the I allele in the patient group was significantly lower than in controls. We found that the frequency of the DD was higher in obese Turkish patients with IR. ACE I/D may be associated with obesity in the .


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Interleukin-10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkey

Yazan: admin Tarih: Oca 21st, 2010 | Kategori:: Gene polymorphisms, Interleukin, schizophrenia

Author(s): Ozbey U (Ozbey, Ulku)2, Tug E (Tug, Esra)1, Namli M (Namli, Mustafa)3
Source: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY Volume: 10 Issue: 5 Pages: 461-468 Published: 2009

Abstract: Schizophrenia is one of the most severe psychiatric disorders, with a worldwide incidence of 1%. Immunological abnormalities have been found to be associated with schizophrenia for decades. Cytokines are key proteins involved in the immune system activation. Interleukin-10 (IL-10), an important immunoregulatory cytokine, is located on chromosome 1q31 32, a region previously reported to be linked to schizophrenia in genetic studies. In the present study it was aimed to examine the IL-10 promoter region’s polymorphic variants in patients with schizophrenia in a of the Elazig Region of East Anatolia, . Polymorphisms at position -1082, -819 and -592 in the IL-10 promoter region were determined in 171 Turkish patients who were diagnosed with schizophrenia, based on the DSM-IV, and 168 healthy controls, by chain reaction ()- (RFLP). We analyzed allele, , and haplotype distributions using a case-control association study. Genotyping was performed by RFLP. Statistically significant differences were observed in both allelic and genotypic frequencies of the -592A/C (Allele, P = 0.034, OR = 1.26, 95% CI 1.02 – 1.56; , P = 0.048), while the other two polymorphisms in distribution of the alleles and genotypes in patients with schizophrenia were not significantly different from those of controls (P > 0.05). Our results show a significant increase of GTA homozygotes (the high IL-10-producing haplotype) in schizophrenic patients compared to control subjects (P = 0.0001). These data suggest that the IL-10 promoter may be one of the susceptibility factors to develop schizophrenia in the , and apparently in all humans.
Document Type: Article
Language: English
Author Keywords: Biological psychiatry; cytokines; genetics; ; schizophrenia
KeyWords Plus: ASSOCIATION; HAPLOTYPES; ; LINKAGE
Reprint Address: Tug, E (reprint author), Abant Izzet Baysal Univ, Izzet Baysal Med Sch, Dept Med Genet, TR-14280 Bolu,
Addresses:
1. Abant Izzet Baysal Univ, Izzet Baysal Med Sch, Dept Med Genet, TR-14280 Bolu,
2. Firat Univ, Fac Med, Dept Med Biol & Genet, TR-23169 Elazig,
3. Hosp Psychiat, Elazig,
E-mail Addresses: esratug@hotmail.com


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