Polymorphisms in Turkish population

Publication year: 2010
Source: Clinica Chimica Acta, Volume 411, Issues 3-4, 2 February 2010, Pages 258-262
Priscilla C., Jaramillo , Cecilia, Lanas , Fernando, Lanas , Luis A., Salazar

 Background: Nitric oxide (NO) from the endothelium, produced by oxidation of l-arginine to l-citruline for the action at the endothelial nitric oxide synthase (eNOS) is considered an important atheroprotective factor. The 894G>T, −786T>C and 4a/4b polymorphic variants of the NOS3 gene have been implicated in the development of coronary artery disease (CAD). We investigated the association between occurrence of CAD documented by angiography and the 894G>T, −786T>C and 4a/4b polymorphisms of the NOS3 gene in Southern Chilean individuals. Methods: A total of 112 unrelated patients with diagnosis of CAD confirmed by angiography and 112 controls were included in this study. The 894G>T and…