Polymorphisms in Turkish population

Publication year: 2010
Source: Osteoarthritis and Cartilage, Volume 18, Issue 2, February 2010, Pages 200-207
G., Moxley , I., Meulenbelt , K., Chapman , C.M., van Diujn , P., Eline Slagboom , …

 Objective: Several research groups have examined osteoarthritis (OA) association with Interleukin-1 (IL-1) region markers and haplotypes. The results have been suggestive for hand OA, negative for knee OA, and conflicting for hip OA. Design: Our aim was to address conflicts employing meta-analytical methods on data from 1238 European-descent cases with various OA phenotypes and 1269 European-descent controls from four study centers. We imputed some missing genotype data and reconstructed IL-1 region extended haplotypes. A previously reported 7-marker IL1A-IL1B-IL1RN extended risk haplotype was tested for association with each specific index phenotype. Results: For hip OA, data from three centers showed heterogeneity of extended-risk-haplotype effect, two panels…