Polymorphisms in Turkish population

Publication year: 2010
Source: Psychiatry Research, Volume 175, Issues 1-2, 30 January 2010, Pages 43-46
Gamze, Kilic , Cem, Ismail Kucukali , Nurcan, Orhan , Elif, Ozkok , Asli, Zengin , …

We examined whether the GRIK3 (T928G) polymorphic variants in patients with schizophrenia are different from those of their first-degree relatives and healthy controls. The study population was composed of 256 patients with schizophrenia, 305 first-degree relatives of schizophrenia patients and 242 healthy control subjects. The GRIK3 (T928G) polymorphism was determined by restriction fragment length polymorphism. The frequency of the TT genotype was predominant, whereas the GG genotype was rare among all groups. The frequencies of GRIK3 (T928G) genotype distributions in the patients with schizophrenia were similar to those of their relatives. The frequency of the GG genotype was significantly higher…