Polymorphisms in Turkish population

Publication year: 2010
Source: Molecular and Cellular Endocrinology, Volume 316, Issue 2, 25 March 2010, Pages 129-139
Sandra, Galic , Jon S., Oakhill , Gregory R., Steinberg

Obesity is characterized by increased storage of fatty acids in an expanded adipose tissue mass and is closely associated with the development of insulin resistance in peripheral tissues such as skeletal muscle and the liver. In addition to being the largest source of fuel in the body, adipose tissue and resident macrophages are also the source of a number of secreted proteins. Cloning of the obese gene and the identification of its product, leptin, was one of the first discoveries of an adipocyte-derived signaling molecule and established an important role for adipose tissue as an endocrine organ. Since then, leptin…