Polymorphisms in Turkish population

Publication year: 2010
Source: Molecular and Cellular Endocrinology, Volume 316, Issue 2, 25 March 2010, Pages 129-139
Sandra, Galic , Jon S., Oakhill , Gregory R., Steinberg

Obesity is characterized by increased storage of fatty acids in an expanded adipose tissue mass and is closely associated with the development of insulin resistance in peripheral tissues such as skeletal muscle and the liver. In addition to being the largest source of fuel in the body, adipose tissue and resident macrophages are also the source of a number of secreted proteins. Cloning of the obese gene and the identification of its product, leptin, was one of the first discoveries of an adipocyte-derived signaling molecule and established an important role for adipose tissue as an endocrine organ. Since then, leptin…

Publication year: 2010
Source: Clinica Chimica Acta, Volume 411, Issues 3-4, 2 February 2010, Pages 258-262
Priscilla C., Jaramillo , Cecilia, Lanas , Fernando, Lanas , Luis A., Salazar

 Background: Nitric oxide (NO) from the endothelium, produced by oxidation of l-arginine to l-citruline for the action at the endothelial nitric oxide synthase (eNOS) is considered an important atheroprotective factor. The 894G>T, −786T>C and 4a/4b polymorphic variants of the NOS3 gene have been implicated in the development of coronary artery disease (CAD). We investigated the association between occurrence of CAD documented by angiography and the 894G>T, −786T>C and 4a/4b polymorphisms of the NOS3 gene in Southern Chilean individuals. Methods: A total of 112 unrelated patients with diagnosis of CAD confirmed by angiography and 112 controls were included in this study. The 894G>T and…

Publication year: 2010
Source: Autoimmunity Reviews, Volume 9, Issue 4, February 2010, Pages 241-245
Claudia, Mendoza-Pinto , Mario, García-Carrasco , Mario, Jiménez-Hernández , Cesar, Jiménez Hernández , Carlos, Riebeling-Navarro , …

Bechet’s disease (BD) is an inflammatory, multi systemic disease with spontaneous remissions and relapses similar to various autoimmune diseases. BD leads to organ damage, including the eyes, skin, joints, etc., which produces various clinical manifestations. The central histopathologic characteristic is systemic vasculitis with perivascular inflammatory infiltrates. The etiopathogenesis is unknown, although immunological abnormalities, possibly induced by susceptible microbiological pathogens, have been postulated.

Publication year: 2010
Source: Cytokine, Volume 49, Issue 2, February 2010, Pages 130-133
S., Prabhu Anand , M., Harishankar , P., Selvaraj

We investigated whether IFN-γ gene +874(A/T) polymorphism influences intracellular interferon gamma expression in T-cell subsets of normal healthy subjects (NHS) and pulmonary tuberculosis patients (PTB). Peripheral blood mononuclear cells were stimulated with live Mycobacterium tuberculosis (MTB) and the intracellular IFN-γ expression was studied using flow cytometry. Genotyping of IFN-γ gene +874(A/T) was done using allele specific polymerase chain reaction. Significantly increased IFN-γ expressing CD3+CD4+ and CD3+CD8+ T cells were observed in NHS with AA genotype compared to TT genotype in unstimulated (p=0.0308 and p=0.0157) and MTB stimulated (p=0.0494 and p=0.0287) cultures and this difference was not observed in PTB patients….